| 초록 |
We developed disulfide cross-linked nanovesicles from amiphiphilic graft polymers, poly(hydroxyethyl aspartamide)-g-polycysteine. The polymer formed vesicular aggregates in aqueous solution and the thickness of shell can be controlled by adjusting the length of hydrophobic chains. The morphology of vesicles can be confirmed by TEM and small angle neutron scattering analysis. The hydrophobic polycysteine formed disulfide cross-linking and hydrogen bond formation by self-oxidation and beta sheet formation, respectively.. Intracellular compartments have high reductive environment though blood stream have low concentration of reducing agent. Consequently, particles are stable in blood stream though they can be destabilized at cancer cells. The anticancer drug, doxorubicin (DOX), was encapsulated within the cavity of vesicles, and anticancer efficacy was evaluated by MTT assay. |
