| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
콜로이드 및 분자조립 부문위원회 |
| 제목 |
Quantum dot-DNA hybrid nanogel for specific DNA assay |
| 초록 |
This talk will introduce a new method to efficiently increase the DNA detection sensitivity to sub-picomolar concentrations through a short single-stranded DNA (ssDNA)-catalyzed formation of DNA hydrogel incorporating Förster resonance energy transfer (FRET) donor-acceptor pairs. A low-copy-number of ssDNA catalyzes the opening cycles of DNA hairpin loops tethered with a FRET acceptor into Y-shaped DNA structures, which are self-assembled with ssDNA-functionalized quantum dots (QDs) into a hydrogel. The self-assembled hydrogel structure of FRET pairs greatly improves FRET signals due to the close spatial proximity. |
| 저자 |
남윤성 |
| 소속 |
한국과학기술원 |
| 키워드 |
DNA assay; DNA nanostructure; quantum dots; energy transfer
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| E-Mail |
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