| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Application of chitosan nanoparticles based on electrostatic interaction of retinol and low molecular water-soluble chitosan |
| 초록 |
This aim of this study was to encapsulate retinol into chitosan nanoparticles and reconstituted it into aqueous solution. Retinol-encapsulated chitosan nanoparticles has a spherical shaphes and its particle size were around 50 – 200 nm according to the drug contents. It was suggested that retinol was encapsulated into chitosan nanoparticles by ion complex at results of FT-IR spectra. Specific peak of chitosan at 1590cm-1 was divided to semi-doublet due to the electrostatic interaction between amine group of chitosan and hydroxyl group of retinol. At 1H NMR spectra, specific peaks of retinol was disappeared when retinol-encapsulated chitosan nanoparticles were reconstituted into D2O while specific peaks both of retinol and chitosan was appeared at D2O/DMSO (1/4, v/v) mixture. XRD patterns also showed that crystal peaks of retinol were disappeared by encapsulation into chitosan nanoparticles. At HPLC study, retinol was stably and efficienctly encapsulated into chitosan nanoparticles. |
| 저자 |
서동혁, 정영일, 장미경, 김동곤, 장민자, 박준규, 장학수, 나재운
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| 소속 |
순천대 |
| 키워드 |
retinol; chitosan; nanoparticle
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| E-Mail |
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