| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 가을 (11/02 ~ 11/03, 한경대학교) |
| 권호 |
11권 2호 |
| 발표분야 |
생물공학 |
| 제목 |
pH-Responsive Hydrogels Composed of Chitosan and Poly(γ-Glutamic acid) by EDC cross-Linking for Controlled Drug Release : Preparation, Characterization and Drug Release Behavior |
| 초록 |
pH-sensitive hydrogels composed of Chitosan and γ-PGA were prepared by the freeze drying method and EDC cross-linked to suppress hydrogel deformation in water. The physical properties, swelling and drug diffusion behaviors were characterized for the hydrogels. In equilibrium swelling study, Chitosan/γ-PGA hydrogels shrunk in pH resions below pKa(2.27) of γ-PGA whereas they swelled above pKa. In the drug diffusion study, the drug permeation rates of Chitosan/γ-PGA hydrogels were directly proportional to their swelling behaviors. |
| 저자 |
박보기, 김구연, 손태일
|
| 소속 |
중앙대 |
| 키워드 |
hydrogels; swelling; drug derivery systems
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| E-Mail |
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