| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Release and characterization of double-layered microspheres containing water-soluble drugs |
| 초록 |
When administering drug into the body, it reveals the decline of drug effect or toxicity. To overcome these problems, double-layered microspheres(DLM) studied with biodegradable polymers had been investigated. In this study, we manufactured DLM using oil-in-water(O/W) solvent evaporation method to increase the encapsulation ratio of 5-FU and to control the release of 5-FU, and to prevent side-effects with changed concentration of PLGA and 5-FU. The DLM is composed of two components; Core consists of the mixture of dextran and 5-FU and corona consists of PLGA. And the sizes of DLM increased with increasing PLGA content but decreased with increasing 5-FU concentration. In SEM observation, the DLM was spherical shape, smooth surface and transparency. The yield of DLM was 70~80%, and encapsulation ratio was 10~20%. Acknowledgement : This research was supported by Establishment of Nanoscopia Center of Excellence (KMOST) |
| 저자 |
고종태1, 이재호2, 모종현1, 육순홍3, 신형식1, 이종문1, 김문석4, 이해방4, 강길선1
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| 소속 |
1전북대, 2한화석유화학 중앙(연), 3한남대, 4한국화학(연) |
| 키워드 |
double-layered microsphere; O/W solvent evaporation method; water-soluble drug
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| E-Mail |
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