| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Elastin-Resilin Block Copolypeptides with Converse Phase Transition Behavior and Their Self-assembled Nanostructures |
| 초록 |
Diblock copolymers having different solubilities self-assemble into diverse nanostructures such as micelles, rods, vesicles or lamellae in response to external stimuli. In this study, we report thermally triggered self-assembly of elastin-resilin diblock copolypeptides with converse phase transition behavior. Elastin-based polypeptide (EBP) with lower critical solution temperature (LCST) was genetically fused with resilin-based polypeptide (RBP) having upper critical solution temperature (UCST). The EBP-RBP diblocks with different block lengths were synthesized and their self-assembled nanostructures were characterized at nanoscale. The EBP-RBP diblocks underwent dual phase transitions as a function of temperature, and different nanostructures were formed with reversibility. These switchable nanostructures with dual thermo-responsiveness would be of great potential for biomedical applications. |
| 저자 |
Aamna Basheer, 이재상, 강민정, 임동우
|
| 소속 |
한양대 |
| 키워드 |
Elastin; Resilin; Temperature responsiveness; Self-assembly; Switchable nanostructures
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| E-Mail |
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