| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Design and Synthesis of Methylene Malonate Compound for Liquid Embolic Material |
| 초록 |
Endovascular embolization is the occlusion of target blood vessels with embolic materials for therapeutic purposes. By blocking the abnormal and weak blood vessels, the vascular rupture and inner bleeding can be prevented. Liquid embolic materials for endovascular embolization are usually liquid state at normal conditions and solidified when they are injected into the blood vessel. Cyanoacrylate monomer is one of the most commonly used liquid embolic materials in the clinic. Methylene malonate is one of the highly reactive monomers that can be rapidly polymerized by weak bases or nucleophiles. Methylene malonate has been applied as adhesives and coating materials but it has not been studied as a liquid embolic material so far. herein, we designed and synthesized the methylene malonate monomer for liquid embolic materials. Methylene malonate is expected to be a meaningful candidate for liquid embolic material due to the rapid polymerization in blood and tunability of chemical structure. |
| 저자 |
박지호, 안철희
|
| 소속 |
서울대 |
| 키워드 |
Liquid embolic material; methylene malonate
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| E-Mail |
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