| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drugs Controlled Release of Doxazosin Multi-Layered Pellet made of Polymer Blending |
| 초록 |
In this study, a multi-layered pellet was composed of a seed layer including a waterswellable agent and a drug layer containing doxazosin as a model drug, a porous membrane and a castor oil layer to control drug release. The pellet is prepared by a fluidized bed coating method. To confirm drug release from polymer blending in multi-layered pellet system, it is prepared by containing different ratio such as hydroxypropylmethylcellulose : ethyl cellulose in drug layer and cellulose acetate : Eudragit RS in membrane. Also, to confirm the effect of oil in drug release, castor oil is coated. As a result, we observed regularly spherical pellet with diameter of 1500 μm. Release pattern of drug is confirmed by dissolution tester in aqueous media. The more the ratio of EC in drug layer, CA in membrane, and castor oil layer in pellet, the less the drug release is observed. Formation and the amount of pores in membrane is observed by SEM. This research was supported by WCU(R31-20029). |
| 저자 |
유동혁, 김세호, 조한수, 홍동현, 정선영, 고마음, 유일수, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
fluidized-bed coater; doxazosin mesylate; castor oil; cellulose acetate; drug release.
|
| E-Mail |
|
