| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 가을 (10/23 ~ 10/25, 대구 EXCO) |
| 권호 |
19권 2호, p.1389 |
| 발표분야 |
미립자공학 |
| 제목 |
Response surface methodological approach to minimize particle size of ibuprofen |
| 초록 |
Ibuprofen is a highly crystalline substance with the pharmaceutical properties of poor solubility and low bioavailability. The size reduction of ibuprofen is needed to improve the solubility. The objective of this study is to minimize the particle size of ibuprofen. Grinding of ibuprofen was carried out using a planetary mill. Grinding parameters were optimized using Box-Behnken experimental design method. The physical characteristics of ground ibuprofen were investigated for the particle size by particle size analyzer. The optimum conditions for the milling of ibuprofen were 290rpm of the revolution number of mill, 24.6g of the weight of sample, and 10 minutes of grinding time. The measured value of the particle size of ground ibuprofen at these optimum conditions was 13.5µm. |
| 저자 |
심철호 |
| 소속 |
상지대 |
| 키워드 |
: ibuprofen; optimization; response surface methodology; Box-Behnken method; grinding
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
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