| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Polymeric micellar nanoplatform for Fenton reaction as novel antibacterial therapeutics agents |
| 초록 |
Reactive oxygen species produced by host phagocytes exert antibacterial action against pathogens. ROS-induced oxidative stress is the governing mechanism for the antibacterial activity of antibiotics. Especially, hydroxyl radical is a strong oxidant which can damage. Ferrous ion is known to convert H2O2 into hydroxyl radicals, referred to as Fenton reaction. Herein, we report a novel antibacterial agent composed of H2O2-generating polymer (PCAE) and iron-containing ferrocene. PCAE was designed to incorporate H2O2-generating cinnamaldehyde through acid-cleavable linkages and self-assemble to form micelles that encapsulate ferrocene. All the experiments in vitro display that ferrocene-loaded PCAE micelles produce hydroxyl radicals to kill E. coli and P. aeruginosa. In addtion, ferrocene-loaded PCAE micelles reduced the lung damages and therefore increased the survival rate of mice. We anticipate that ferrocene-loaded PCAE micelles hold great potential as a novel of antibacterial agents. |
| 저자 |
이동원1, 장미경2, 나재운2, 양원석1, 김남홍2, 박성철2
|
| 소속 |
1전북대, 2순천대 |
| 키워드 |
antibacterial; hydroxyl radical; Fenton reaction; polymers; micelles
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| E-Mail |
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