| 초록 |
Fluoroalkylated organic compounds play significant roles in the pharmaceutical, agrochemical, and material sciences owing to the substantial influence that fluorine substitution has on the physical and chemical properties of substances. Visible light-induced methods allowed access to fluoroalkyl group-containing molecules, such as –CF3, –CF2R, –CF2SPh, and –CF2OPh groups. In the studies, electron deficient carbon-centered fluoroalkyl radicals were successfully generated by the appropriate choice of fluoroalkyl source, photocatalyst, additives, and solvent. Notably, we have observed that additives significantly affect the efficiencies and selectivities of these reactions and can even change the outcome of the reaction by playing additional roles during its course. By understanding the roles of additives, we developed several controlled fluoroalkylation reactions where different products were formed selectively from the same starting substrates. |
