| 초록 |
The progress in photonic materials have stimulated significant progress in photomedicines. However, the finite depth of light penetration is a serious limitation constraining their clinical applications. Here, we developed upconversion nanoparticle/hyaluronate-rose bengal (UCNP/HA-RB) complex for deep tissue photoadhesion using near infrared (NIR) light. Compared to conventional invasive treatments such as suturing and stapling, UCNP/HA-RB complex could be noninvasively delivered into deep tissue and accelerate wound healing on NIR laser irradiation. The NIR light triggered UCNP to illuminate green light and activate RB in HA-RB conjugate under the skin tissue. HA facilitated the penetration of RB into the collagen layer of dermis. After characterization of the UCNP/HA-RB complex by fluorometry, DLS and TEM, we could confirm the wound healing effect by ex vivo and in vivo experiments including tensile test of skin tissues, collagen fibrillogenesis measurement and histological analysis. |
