| 초록 |
Exosomes are cell-derived vesicles offer active yet specific cellular attraction to drug delivery applications. In this study, we propose a novel active drug delivery system which is established by using lipid/polymer hybrid vesicles with fusogenic peptide conjugates. The lipid/polymer hybrid vesicles are fabricated by co-assembly of phosphatidylcholine and poly(ethylene oxide)-b-poly(dimethyl siloxane)-b-poly(ethylene oxide). Thanks to large size and slow dynamics of amphiphilic triblock copolymers at the bilayer membrane, the hybrid vesicles show long-circulating time and high drug loading efficiency. To evaluate the cell affinity of fusogenic exosomes, the interaction force of the exosomes with cells is characterized via surface force apparatus. Finally, in vitro cell-penetration study demonstrates the practical applicability of our artificial exosome as a remarkable cell delivery nanocarrier. |
