| 초록 |
Gellan gum(GG) is known to be one of biocompatible materials that resemble living tissues, continuously delivering stem cells or general cells. However, there is a drawback in that it is incapable of injecting through a needle. In this study, GG solutions with agar were prepared. The obtained scaffolds were tested for rheological properties and condrocytes adhesion, morphology and proliferation. Results shown that the addiction of agar allows to extrude the material producing micro-porous scaffolds. Biological evaluation demonstrated that the adhesion and proliferation of chondrocytes increase with the presence of agar in the final structure. The solutions composed of GG/agar represent an efficient, fast and high reproducible methodology with the potential to be used as injectable hydrogel for cartilage healing purposes. This research was supported by a grant of the Korea Health Technology R&D Project through the KHIDI, funded by the Ministry of Health &Welfare(HI15C2996) |
