| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Thiol-Responsive Gemini Poly(ethylene glycol)-Poly(lactide) with a Cystine Disulfide Spacer as an Intracellular Drug Delivery Nanocarrier |
| 초록 |
Thiol-responsive gemini micelles consisting of hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic polylactide (PLA) blocks with a cystine disulfide spacer were reported as effective intracellular nanocarriers of drugs. In the presence of cellular glutathione (GSH) as a reducing agent, gemini micelles gradually destabilize into monomeric micelles through the cleavage of the cystine linkage. This destabilization of the gemini micelles changed their size distribution, with the appearance of small aggregates, and led to the enhanced release of encapsulated doxorubicin (DOX). The results obtained from cell culture via confocal laser scanning microscopy (CLSM) for cellular uptake, as well as cell viability measurements for anticancer efficacy suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers. |
| 저자 |
하태린, 김은주, 정상원, 이세근, 이성준, 김현철
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| 소속 |
대구경북과학기술원 |
| 키워드 |
gemini surfactants; drug delivery systems; micelles; disulfide-thiol exchange; biodegradable; stimulus-sensitive polymers
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| E-Mail |
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