| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Gold-some Amplified Plasmonic Immunoassay based on Viral Fusion for Point-of-Care Testing of Respiratory Virus |
| 초록 |
We propose a plasmonic immunoassay based on a target specific organic-inorganic hybrid nanoparticle with an antibody-functionalized glass substrate. The hybrid nanoparticle (Gold-somes) encapsulates gold nanoparticles (GNPs) which are used to amplify the detection signal. In the presence of the virus, the glass substrate will capture the target, and viral fusion of Gold-somes will follow. During the viral fusion, encapsulated GNPs will escape the probe. With the addition of reducing agents, freed GNPs will form aggregates, resulting in a color change with respect to a peak shift. We conducted experiments to synthesize the hybrid nanoparticles (Gold-somes) and to optimize the reaction environment for the glass substrate. Eventually, we expect our plasmonic immunoassay platform be applied for point-of-care testing via colorimetric virion detection. |
| 저자 |
문예솔, 이소정, 박근선, 김진영, 박채원, 함승주
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| 소속 |
연세대 |
| 키워드 |
Polymersome; Gold nanoparticle (GNP); membrane fusion; respiratory virus
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| E-Mail |
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