| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Glucose-capturing polymer nanoparticles for cancer theranosis |
| 초록 |
Since conventional cancer therapeutics may induce side effects such as renal disorder, hair loss, etc., functionalized polymer nanoparticles have been extensively investigated to provide new opportunity for targeted delivery of bioactive agents. Most tumor cells show high aerobic glycolysis due to critical damage of mitochondrial respiration and hypoxia stress in the cells. We thus hypothesized that glucose-capturing nanoparticles could be effective to induce glucose deprivation of cancer cells, leading to apoptotic cell death. Phenylboronic acid, which is known to reversibly bind to diols of glucose, was chemically introduced to the polysaccharide backbone and nanoparticles were prepared via self-assembly in water. Various physiochemical properties, anti-glycolysis effect, and apoptosis induction of glucose-capturing nanoparticles were investigated in vitro. We also tested the efficacy of the nanoparticles as a theranostic system using a tumor-bearing mouse model. |
| 저자 |
이장욱1, 조민영1, 손세진2, 김광명2, 권익찬2, 이근용1
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| 소속 |
1한양대, 2한국과학기술(연) |
| 키워드 |
glucose-capturing nanoparticles; cancer metabolic control; glucose deprivation; phenylboronic acid; glycol chitosan
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| E-Mail |
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