| 초록 |
Poly(ethylene glycol) (PEG) is biocompatible polymer used in cosmetic, and medical applications. PEG has various advantages, such as superior biocompatibility, low immunogenicity, and low toxicity. In this study, a novel hydrophobic epoxide monomer, tetrahydrofuranyl glycidyl ether (TFGE) was introduced, it could give biocompatible PEG-based amphiphilic block copolymer by anionic ring-opening polymerization (AROP). The amphiphilic copolymer with TFGE moieties makes stable micelle in aqueous solution. In addition to, the micelles with TFGE moieties, especially, have acetal group for acid degradation, therefore it would release drugs to target acidic tumor cells. The chemical structure of TFGE and PEG-b-PTFGE is confirmed using various NMR technique, mass spectrometry and GPC. In addition to, the behavior of PEG-b-PTFGE in aqueous solution is confirmed using pyrene fluorescence measurements and CMC studies. |
