| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생물공학 |
| 제목 |
Pancreatic cancer metastasis tracking using Mass-spectrometry based N-glycan profile analysis |
| 초록 |
The abnormalities in glycosylation profile manifested among cancer cells has been recognized for its biomarkers towards assessing tumor progression. This study is the first diagnostic biomarker profiling on three types of pancreatic cancer cells (Capan-1, Panc-1 and MIA PaCa-2) from different sites of pancreatic tumor. 41 N-glycans present on the surface of normal and cancerous pancreatic cells were idenfied and relatively quantified using MALDI-TOF MS and MALDI-QIT-TOF MS/MS analysis coupled with solid-phase permethylation. These findings indicate that they can be used to differentiate normal and pancreatic cancer cells by specific N-glycosylation profile changes, as well as provide more information about their location and metastatic potential. |
| 저자 |
안다희1, 황철환1, 박한규1, 송원석2, 정윤이1, 김성민1, 김윤곤1
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| 소속 |
1숭실대, 2서울대 |
| 키워드 |
Pancreatic cells. N-glycans; Qualitative and quantitative analysis; MALDI-TOF MS
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| E-Mail |
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