| 학회 |
한국공업화학회 |
| 학술대회 |
2010년 봄 (05/13 ~ 05/14, BEXCO(부산)) |
| 권호 |
14권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Polypyrrole nanotube biosensor conjugated with Hsp90 for anti-cancer agent detection |
| 초록 |
A rapid and efficient strategy to detect novel heat shock protein 90 (Hsp90) inhibitors as anti-cancer agents was developed with field-effect transistor (FET) sensor based on carboxylated polypyrrole nanotubes (CPNTs). First of all, the CPNTs were successfully fabricated by using cylindrical micelle templates in a water-in-oil emulsion system. On the basis of CPNTs, a FET sensor platform was constructed to detect specific biological entities by using a buffer solution as a liquid-ion gate.Hsp90 as the molecular recognition element was bonded to the nanotube surface. This FET sensor provided a convenient and sensitive method to observe the affinity between Hsp90 to Hsp90 inhibitors in real-time. |
| 저자 |
박선주, 장정식
|
| 소속 |
서울대 |
| 키워드 |
Conducting polymer; Hsp90; nanotubes; FET
|
| E-Mail |
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