| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Application of PEGDC/PEO Hydrogels Crosslinked with Electron Beam as Postoperative Adhesion Barriers |
| 초록 |
Postoperative adhesions are a significant problem of abdominal surgery and cause the potentially lethal bowel obstruction. The cross-linked polyethylene glycol dicarboxylates (PEGDC)/ polyethylene oxide (PEO) hydrogel was developed for the anti-adhesion barrier. Various PEGDC/PEO compositions were irradiated using an electron beam with several beam intensities in order to obtain various degrees of crosslinked hydrogels. Hydrogel film containing 10% of PEGDC exhibited high gel contents (86±1.4%), strong mechanical strength (1.78±0.19MPa) and sufficient tissue adherence (8.67±0.57cN) to make sure that the film was easily placed onto tissue with good adherence during the wound healing process. The results proved the possibility of the superficial production of a film with high mechanical strength and sufficient tissue adherence with very low cytotoxicity and hemolysis as an anti-adhesion barrier. |
| 저자 |
Haryanto1, Sing Deepti2, Sungsoo Han3, Jintae Kim4, Seong-Cheol Kim5, Junhyuk Son2
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| 소속 |
1Departement of Advanced Organic Materials Engineering, 2Yeungnam Univ., 3Departement of Nano, 4Medical, 5Polymer Materials |
| 키워드 |
crosslinked hydrogels; polyethylene glycol dicarboxylates; electron beam; anti-adhesion barrier; mechanical strength.
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| E-Mail |
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