| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Fabrication of Drug-Eluting Beads with Inherent X-ray Opacity and Biodegradability for Transarterial Chemoembolization |
| 초록 |
Drug-eluting beads (DEBs) are size-calibrated microspheres used for transarterial chemoembolization (TACE) procedures, occluding the blood supply to the hepatocellular carcinoma (HCC). Conventional DEBs have some limitations in their biodegradability or x-ray visibility, which cause operational inconvenience and risk of non-target embolization. In this research, x-ray contrast agent-incorporated polymeric microparticles (MPs) were fabricated with a double-emulsion method for the application to TACE. The size distribution of the final product was analyzed with an optical microscope. The x-ray visibility was determined with a real-time C-arm device. The size of MPs was about several hundred micrometers, and it showed narrow size distribution. MPs were determined to have enough x-ray attenuation property to be visualized with a C-arm device. In conclusion, it is confirmed that the polymeric MPs developed in this study have high potentials for the treatment of cancer. |
| 저자 |
전성익1, 제환준2, 안철희3
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering |
| 키워드 |
Polymeric Microsphere; Transarterial Chemoembolization; Contrast Agent
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| E-Mail |
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