| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.94 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Chitosan Derivatives for DNA Carrier |
| 초록 |
Chitosan has been sought as the non-viral vectors beacuse it has several advantages such as biocompatibility, biodegradability, and low toxicity. However, low specificity and low transfection efficiency of chitosan as the DNA carrier need to be overcome prior to clinical trial. In this study, chemical modification of chitosan was tried to enhance cell specificity and transfection efficiency. Also, chemical modification of chitosan was performed to increase stability of chitosan/DNA complex.
|
| 저자 |
조종수;박인규;김태희;최윤재;김수일;나재운;T. Akaike |
| 소속 |
서울대 농생명공학부;서울대 농생명공학부;서울대 농생명공학부;서울대 농생명공학부;서울대 농생명공학부;순천대 고분자공학과;Department of Biomolecular Engineering |
| 키워드 |
chitosan; gene carrier; chemical modification; hepatocyte-targeting
|
| E-Mail |
|
