| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Hydrogel with microtubular hollow structures for microvascularperfusion in ischemic model |
| 초록 | While angiogenesis is the key factor to treatischemic disease, angiogenesis induction such as local treatment withpro-angiogenic molecules has critical side effects including inflammatorycoupling, tumorous vascular activation, and off-target circulation. Here, astructural angiogenic induction is applied to physically engineerthree-dimensional channel networks in ischemic region. Microchannel networksare generated in a gelatin hydrogel to overcome the diffusion limit ofnutrients and oxygen three-dimensionally. Hydrogel implantation in mouse andporcine models of hindlimb ischemia rescues severely damaged tissues by theingrowth of neighboring host vessels with microchannel perfusion, mediated bysize-specific regenerative macrophage polarization. |
| 저자 | 윤정기 |
| 소속 | 중앙대 |
| 키워드 | Microchannel; ischemic disease; hydrogel |
