| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Core-Functionalized Pluronic Micelles: Doxorubicin Conjugation in Micelle Core via Acid Cleavable Linkage |
| 초록 |
Novel polymeric micelles, self-assembled from a biocompatible triblock copolymer of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) having multiple hydroxyl groups in the middle segment, were prepared to solubilize moderately soluble drug doxorubicin (DOX) by conjugating the drug via acid cleavable linkage. The functionalized triblock copolymer was synthesized using secondary amine mediated epoxide ring-opening reaction. The resultant polymer self-assembled into micelle in aqueous solution having a diameter of 88.5±6.3 nm and showed extremely low toxicity. DOX molecules were conjugated to the copolymer via hydrazone linkage to produce DOX conjugated copolymer. Release of DOX was pH-dependent showing higher release rate at pH 5.0 compared with that at pH 7.4, suggesting that the micelles specifically release DOX in endosomal environment. They also exhibited higher cytotoxicity than free DOX indicating that they were more capable of cell uptake than free DOX. |
| 저자 |
이유한, 박성영, 박태관
|
| 소속 |
한국과학기술원 생명과학과 |
| 키워드 |
polymeric micelle; doxorubicin; pluronic; conjugation
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| E-Mail |
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