| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
기능성 고분자 (포스터발표만 진행) |
| 제목 |
Selectively functionalized mesoporous silica particles with the PEGylated outer surface and the doxorubicin grafted inner surface |
| 초록 |
We prepared selectively functionalized mesoporous silica particles (SMSPs) with a polyethylene glycol-grafted outer surface and a doxorubicin-grafted inner surface for drug delivery. This material was fabricated by co-condensation of an amphiphilic organotriethoxysilane with a thermally cleavable urethane bond and tetraethoxysilane. The outer surface of the silica particles was functionalized by grafting with 3-(triethoxysilyl)propyloxy–PEG. The PEG-grafted SMSPs were refluxed in methanol in the presence of HCl, resulting in the removal of surfactant molecules and the formation of a methoxy urethane group tethered to the pore wall. After the reaction of the methoxy urethane group with hydrazine, doxorubicin was chemically introduced into the pores through a pH-sensitive hydrazone linkage. A high loading content was achieved through chemical loading followed by physical loading. The doxorubicin-loaded SMSPs showed a pH-sensitive and sustained release behavior. |
| 저자 |
전재범, 장지영
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| 소속 |
서울대 |
| 키워드 |
Mesoporous silica; Drug delivery; Doxorubicin; pH-sensitive; Surface modification
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| E-Mail |
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