| 초록 |
The MO/water system, cubic phase, can be used as a delivery vehicle for hydrophobic and/or hydrophilic materials. Monoolein (MO) cubic phases entrapping hydroxypropyl β-cyclodextrin (HPβCD)/minoxidil (MXD) complex were prepared by hydrating molten MO with the complex solution. To obtain the nanoparticles of cubic phase(so called cubosomes), Pluronic F127 solution in the buffer was added to MO gel so that the ratio of the polymeric surfactant to MO was 15:100. In vitro skin permeations and the skin retentions of MXD loaded in the nanoparticles and of MXD solution in PG/DW/EtOH, PG/water and EtOH/water were observed in diffusion cells. |
