| 초록 |
A human chromosome is a 2m DNA fiber that consists of a 30-nm assembly with histones (histone octamer) and other proteins in the nucleus of a human cell. The chromosome is compacted into a size of about tens to a hundred cubic micro-meter. Thanks to recent advances in chromosome conformation technology (Hi-C), There have been many reports that chromatin is partitioned into genomic functional domains called topologically associated domains (TADs). The way chromatin is condensed inside the nucleus is largely related to TAD and, thereby, is involved in the regulatory process significantly. Despite its importance, owing to experimental limitations, the details of the hierarchal structure of chromatin are not well understood. In this talk, we present an in-silico study of the underlying static and dynamic structure of a single polymer chain which is a computational representation of chromatin under spherical confinement to provide insights about it. |
