| 초록 |
Engineering bone tissue has gained considerable interest in recent years due to various clinical issues and the limited availability of suitable bone grafts. Bone healing is orchestrated by a myriads of chemical and mechanical signals provided from mesenchymal stem cells and extracellular matrix (ECM). Therefore, it is of importance to consider engineering strategies to direct multi-facet processes in a bone microenvironment for regeneration of physiologically relevant bone tissue. We have been developing fibrous materials with capability of providing chemical and geometrical signals, and investigating their contribution to guiding bone formation. In this presentation, how the guidance of in vitro stem cell function and in vivo bone formation can be affected by functionalized nanofibrous materials will be discussed. |
