| 학회 | 한국화학공학회 |
| 학술대회 | 2010년 가을 (10/21 ~ 10/22, 대전컨벤션센터) |
| 권호 | 16권 2호, p.1227 |
| 발표분야 | 고분자 |
| 제목 | Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical Imaging |
| 초록 | We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe2O4 magnetic nanocrystals (MNCs). Py- PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent 1- pyrenebutyric acid through an esterification process, is capable of self-assembly and maintaining a high UV fluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent and magnetic properties as well as maintaining high water-solubilit. Consequently, we proved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models. |
| 저자 | 임은경, 함승주, 양재문, 허용민, 서진석 |
| 소속 | 연세대 |
| 키워드 | nanoprobe; magnetic resonance imaging; multimode; fluorescent |
| 원문파일 | 초록 보기 |
