| 초록 |
Gelatin is main constituent of the skin, bone, and connective tissue of animal. It has properties such as biocompatibility and biodegradability. it is widely used to biomaterial for drug delivery. Therefore, gelatin derivative was used to form particle containing drug and to make sustained drug effect to injection site. Azido group was introduced into the gelatin for preparation of UV-curable Gelatin derivative. If Az-Gelatin particle form was injected into the body, it was slowly biodegraded and made a long-lasting effect on a certain site. 1H-NMR and FT-IR spectroscopy were demonstrated that azido group was introduced into Gelatin. The ability to encapsulate drug was confirmed by fluorescent protein using fluorescence microscope. Based on these characteristics, Az-Gelatin is expected to be application in medical field. |
