| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | For cancer therapy with photosensitizer facilated pH sensitive polymeric nanomedicine loaded drug. |
| 초록 | To treat the various cancer, many carriers have been developed. Especially, one of them is nanoparticles(NP) for drug delivery, which is called nanomedicine. But, they have some limitations such as poor intracellular delivery and low escaping efficiency from endolysosome. Thus, cancer therapy using nanomedicine is required a improve intracellular drug delivery and endolysosomal escape using stimuli-sensitive polymer. In this study, we fabricate the photosensitizer(PS) conjugated pH-sensitive polymeric nanomedicine loaded drug. Our system is sensitive with low pH of tumor microenvironment resulting for the increased drug delivery efficiency. In addition, cancer cell internalization can enhance by generating a single oxygen by PS. We demonstrated a great method in cancer therapy by leading disassemble of nanomedicine due to their pH sensitivity that trigger drug release. |
| 저자 | 임병준, 이충성, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Photodynamic therapy; drug delivery system |
