| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
ROS-responsive thioether-bearing polymers for efficient intracellular drug delivery in cancer cells |
| 초록 |
Reactive oxygen species (ROS)-responsive drug carrier have been attracted for cancer-selective drug delivery since ROS is one of the representative features of cancer cells. Thioether-bearing polymers (TEP) were synthesized to achieve ROS-responsive drug delivery. PL-loaded TEP nanoparticles (PL-TEP NPs) were fabricated to deliver hydrophobic piperlongumine (PL) into cancer cells via a nanoemulsion method. PL is one of the pro-oxidant agents that induce oxidative stress in cancer cells. PL-TEP NPs showed ROS-sensitive disassembly, which leads to efficient cytoplasmic release of PL in MCF-7 human breast cancer cells. Moreover, cancer-specific cytotoxicity of PL-TEP NPs was achieved due to the increase of intracellular ROS in cancer cells. This study demonstrates that PL-TEP NPs are promising stimuli-responsive drug carriers for intracellular delivery of hydrophobic PL. |
| 저자 |
김윤석1, Quan Hoang Truong2, Giang Thuy Nguyen Cao2, 심민석1
|
| 소속 |
1인천대, 2Incheon National Univ. |
| 키워드 |
thioether; nanoparticles; piperlongumine; cancer therapy; pro-oxidant therapy
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| E-Mail |
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