| 초록 |
Anticancer protein drugs are superior to chemical drugs in terms of specificity, therapeutic efficacy, and safety. Hence, they are widely utilized for treatment of various diseases including cancers. However, due to poor cellular permeability and fragility of most proteins, intracellular delivery of proteins is challenging. In this work, we develop the calcium carbonate-based hybrid nanoparticles for efficient intracellular protein delivery. An apoptotic protein, cytochrome C (Cyt C) loaded nanoparticles were prepared by poly(ethylene glycol)-b-polyaspartate) (PEG-b-PAsp) mediated in-situ CaCO3 mineralization in the presence of Cyt C. Cyt C-loaded calcium carbonate mineralized nanoparticles induced effective apoptosis of cancer cells. |
