| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Ocular delivery of brimonidine tartrate using thermo-gelling polymer for glaucoma therapy |
| 초록 |
Conventional eye drops are often eliminated rapidly after administration, leading to a short residence time in the pre-corneal area and a limited transcorneal absorption. Here, a new thermo-sensitive hexanoyl glycol chitosan (HGC) was synthesized and utilized to develop a HGC based eye drop formulation. The thermo-sensitive sol-gel transition of HGC was controlled in a temperature range of 25 to 50 ℃ by modulating the degree of N-hexanoylation. The MTT assay and Live/Dead assay showed that HGC has low cyto-toxicity at the concentration of 0.25-1.25 wt%. The in vivo ocular delivery efficiency of brimonidine tartrate using aqueous HGC solution (BRT-HGC) were evaluated and compared to that of Alphagan P using rabbit. The intraocular pressure lowering effect of BRT-HGC solution was extended to 14 hr. The HGC formulation demonstrated enhanced preocular retention due to thermos-sensitive viscosity increase, improving the drug absoption. |
| 저자 |
허강무1, 최영빈2, 박성영3, 강선웅4, 조명옥1, 허범강4, 박천권2, 조익성2
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| 소속 |
1충남대, 2서울대, 3한국교통대, 4안전성평가(연) |
| 키워드 |
Hexanoyl glycol chitosan; thermogel; Brimonidine; Intraocular pressure
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| E-Mail |
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