| 초록 |
Conventional eye drops have limited effectiveness as a result of low drug bioavailability due to rapid clearance. To resolve this, we propose nanostructured microparticles (NM) for topical drug delivery to the eye. The NM are composed of a mucoadhesive material and along with a large specific surface area from the nanostructures, they can adhere to the mucous layer better, hence prolonged preocular retention. While staying longer at the eye surface, drugs can be released in a sustained manner. Therefore, the NM can improve bioavailability of ophthalmic drugs. For this, we prepare the NM composed of poly(lactic-co-glycolic acid) and poly(ethylene glycol). We also fabricate the microparticles of mesoporouse silica and metal-organic framework. , We examine the intraocular pressure (IOP) and drug concentration in the aqueous humor (AH) after administration of the drug-loaded NM in vivo, where the efficacy improved twice larger than that obtained with Alphagan P, the marketed eye drops. |
