| 초록 |
Local anesthetics are widely used to relief pain after surgery, trauma, or medical procedures by blocking of propagation of the nerve impulse. Although the local anesthetics are introduced for human in the 1800’s, their safety and short duration of action issues are still remained as significant challenge for clinical practices. To compensate the limitations, the encapsulation of local anesthetics in liposomes and biodegradable polymers are recently introduced. However, the difficult manufacturing procedures, toxicity of metabolite compounds and sometimes unexpected burst release are also reported. In this study, we prepared an ion-complexed lidocaine (icLD) which can permit sustained release of the local anesthetics, and thus may be an appropriate system for prolonged pain relief without any additional biomaterials. The drug release behavior, cytotoxicity (in vitro); and analgesic effect (in vivo, rat animal model) were investigated. |
