| 초록 |
Inspired by distinctive hydrophilic/superhydrophobic hybrid micro-/nano-structured surfaces found in Namib desert beetle, we developed spheroid-forming surface called 'spheroform' on which the size of therapeutic spheroids are precisely controlled, and cell viability in the spheroids is increased compared to existing methods. Also, we found that the cellular spheroids formed on spheroform exhibited superior properties due to the unique quasi-spherical environments. Especially, Glucose sensitivity of islet cell spheroids is increased by 200%, and secretion of vascular endothelial growth factor from mesenchymal stem cell spheroids is increased to 300%. |
