| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Blend System Hydrogels with Highly Increased Mechanical Properties for Islet Cell Delivery |
| 초록 |
Hydrogels are of great interest as potential candidates for protein delivery carrier and cell proliferation scaffold because they contain a lot of water. In this study, we designed a novel blend system injectable hydrogel with high mechanical properties for islet cell delivery carrier. Firstly, the two hydroxyl groups of Pluronic F127 was simply modified into two types of functional groups, thiol and pyridyl disulfide, respectively. In physiological environment, gelation occurs firstly via micelle packing mechanism of Pluronic F127 and thiol-disulfide exchange reaction happens after micelle packing mechanism. The properties of resultant chemically as well as physically crosslinked Pluronic F127 hydrogels exhibited highly increased mechanical properties in physiological environment. Further, by in vivo experiment, we confirmed that this hydrogel system can be applied to islet cell delivery system for controlling high glucose level in blood. |
| 저자 |
이승용, Muhammad Rezwanul Haque, 정지헌, 전성익, 변영로, 안철희
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| 소속 |
서울대 |
| 키워드 |
hydrogel; islet delivery; cell delivery
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| E-Mail |
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