| 초록 |
General vocal fold paralysis causes incomplete vocal fold closure and it results in dysphonia and dyspnea. Various techniques have been proposed for the treatment of vocal fold paralysis. Recently, the injection laryngoplasty techniques for managing of glottal insufficiency have gained popularity because of its initial low cost, minimal invasiveness, and low morbidity as compared to surgical repair methods. A number of injectable substances have been adapted in the clinical practice, however, relatively short-term volume stability, inflammation, granuloma formation, and decreased vocal fold vibration are considered as limitations for practical use. In this study, we prepared plasmid DNA complex–loaded alginate/hyaluronic acid (HA) hydrogel dispersed with polycaprolactone microspheres, as an injectable bulking agent for the treatment of vocal fold paralysis. From the results, the pDNA-loaded injectable bulking agent may be a good system for the treatment of vocal fold paralysis. |
