| 초록 |
Hyaluronic acid (HA) is a naturally occurring linear polysaccharide comprised of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine, linked together via alternating β-1,4 and β-1,3 glycosidic bonds. It is a biodegradable, biocompatible, non-immunogenic and non-thrombogenic polymer. Hence, has been widely used in a range of biomedical applications. However, it exhibits poor mechanical properties and adhesive strength. The hydroxyl and carboxyl groups in HA can be functionalized with groups such as thiol, hydrazide and methacrylate. In particular, methacrylated hyaluronate (HAMe) have been widely investigated as the acrylate groups can be crosslinked using photoinitiator in the presence of UV light. The mechanical properties can be controlled by varying either molecular weight of HA, the degree of methacrylation or macromer concentration. In this report, we compare the mechanical properties and adhesive strength of HAMe hydrogels having different degree of methacrylaion. |
