| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Targeted delivery of apoptotic nanovesicles modulating inflammatory responses for cardiac repair |
| 초록 |
Inflammation plays an important role in the pathophysiology of cardiac remodeling and heart failure. Thus, the modulation of inflammatory response could be potentially effective approach in myocardial infarction (MI) treatment. Herein, we fabricated apoptotic fibroblast-derived nanovesicles (ApoNVs) conjugated with ischemic myocardium-targeting peptide and macrophage-targeting molecule. The ApoNVs actively targeted to macrophages in ischemic myocardium and were phagocytosed by macrophages. Uptake of ApoNVs not only reduced the inflammatory responses but also increased anti-inflammatory effects of macrophages by polarizing M1 macrophages to M2 macrophages. This study demonstrates an effective delivery strategy to modulate inflammatory function of macrophages for MI repair. |
| 저자 |
이주로1, 박봉우2, 박훈준2, 정윤기1
|
| 소속 |
1한국과학기술(연), 2카톨릭대 |
| 키워드 |
Apoptotic bodies; immunomodulation; myocardial infarction; nanovesicles
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| E-Mail |
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