| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells |
| 초록 |
Atherosclerosis and vascular inflammation are caused by various vascular endothelial cell dysfunctions. Gene therapy is a promising way to treat the vascularrelated diseases by controlling the level of various factors playing a crucial role in the developing those disease. However gene delivery efficiencies of human vascular endothelial cells (HUVEC) are generally low due to a high susceptibility of these cells to the normal transfection condition. To transfect highly sensitive HUVEC, therefore, we developed a hybrid superparamagentic iron oxide nanoparticle- branched polyethylenimine magnetoplexs (BPEI-SPION) which could rapidly move to the cells in the presence of an external magnetic field. We synthesized it by covalently conjugating LMW BPEI to the SPION and characterized the physicochemical properties of it. Finally we demonstrated the BPEI-SPION could transfect the therapeutic genes into HUVEC efficiently with high cell viability in a short time on the magnetic field condition |
| 저자 |
남궁란1, Kaushik Singha1, 유미경2, 전상용3, 김영숙4, 안용근4, 박인규4, 김원종1
|
| 소속 |
1포항공과대, 2광주과학기술워, 3광주과학기술원, 4전남대 |
| 키워드 |
Magnetofection; Superparamagnetic iron oxide; Polyethylenimine; Gene delivery; Atherosclerosis
|
| E-Mail |
|
