| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Clustered Magnetite Nanocrystals Crosslinked with PEI for Efficient siRNA Delivery |
| 초록 |
Magnetofection has been utilized as a powerful tool to enhance gene transfection efficiency via magnetic field-enforced cellular transport processes. In this study, we developed magnetite nanocrystal clusters (PMNCs) crosslinked with polyethylenimine (PEI) for magnetically triggered intracellular delivery of small interfering RNA (siRNA). PMNCs were produced by surface coating of catechol-functionalized branched polyethylenimine (bPEI) around magnetite nanoparticles. They could form nanosized polyelectrolyte complexes with negatively charged siRNA molecules, and then efficiently delivered them into cancer cells upon exposure to an external magnetic field within a short time. |
| 저자 |
박지원, 배기현, 박태관
|
| 소속 |
한국과학기술원 |
| 키워드 |
siRNA; magnetite nanocrystal clusters; branched polyethylenimine; Gene delivery; Magnetofection
|
| E-Mail |
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