| 초록 |
In this study, polyethylene glycol (PEG) modified melanin nanoparticles (MNPs) were prepared (PEG-MNPs). A model chemotherapy drug, doxorubicin (DOX), was loaded into the PEG-MNPs with different concentrations. TEM images showed that DOX-PEG-MNPs are spherical-shaped and 15±2.2 nm in diameter. FTIR spectroscopy analysis demonstrated that MNPs were successfully modified with PEG. The release behavior of DOX from MNPs was found to be primarily diffusion controlled. In vitro cytotoxicity assays demonstrated that DOX-PEG-MNP was able to inhibit the proliferation of human breast cancer cells. The results confirm that MNPs could be used as a nanocarrier for controlled and prolonged release of the different cancer therapeutics. |
