| 초록 |
Melanin, a biocompatible heterogeneous polymer, has recentlybeen applied in the biomaterial field. Most of the melanin nanoparticle foundin natural organisms are insoluble. Hence, a further application is limited.For the general application of melanin, the chemical synthesis method (cMNP)has been regularly used owing to the simple process compared to enzymaticsynthesis (eMNP). In this study, we synthesized homogenously dispersed solublemelanin under acidic conditions using a one-step tyrosinase reaction. Theenzymatically synthesized melanin is examined by mass spectrometer, UV and IRspectrometry, scanning electron microscopy method. Structure andphysicochemical analysis revealed that acidic conditions could successfullyreduce an uncontrolled crosslinking between amine and quinone and thus inhibitthe formation of the agglomerate. As a result, we showed potential applicationson enzymatically synthesized soluble melanin as a biomedical material. |
