| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 |
22권 2호, p.2564 |
| 발표분야 |
바이오메디컬 소재 및 응용 한·일 국제 심포지엄(특별 심포지엄) |
| 제목 |
Therapeutic effects of trehalose liposomes against carcinoma in vitro and in vivo |
| 초록 |
Trehalose liposomes (DMTre) composed of L-α-dimyristoylphosphatidylcholine (DMPC)and trehalose surfactants have been produced. Inhibitory effects of DMTre on the growth of various tumor cells along with apoptosis were obtained in vitro. The apoptotic signal passed through mitochondria, caspase-9 and 3, first, secondly through caspase-8 and 3 after fusion and accumulation of DMTre into tumor cell membrane along with increase in membrane fluidity. Furthermore, therapeutic effects of DMTre against xenograft mouse models of carcinoma were obtained in vivo leading to apoptosis. No side effects of DMTre were recognized in mice on the basis of biochemical and hematological tests. |
| 저자 |
Yoko Matsumoto |
| 소속 |
Department of Life Sciences |
| 키워드 |
antitumor; liposome; trehalose; apoptosis
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| E-Mail |
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| 원문파일 |
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