| 초록 |
Heat shock proteins (HSPs) are molecular chaperones, and have been known to be a fundamental protein in various biological reactions. The expression of HSPs has been implicated in the regulation of apoptosis, as a modulator of P53 protein function. The HSP27 can be expressed in response to different types of stress, such as thermal elevation, mechanical stimulus, chemical reagent, and pH variation. The HSP27 expression of primary fibroblasts adherent to alginate hydrogels modified with various RGD peptides was investigated. The expression level of HSP27 decreased as the spacer arm length of adhesion peptides increased. This finding clearly indicates that stress applied to cells adherent to synthetic extracellular matrices can be controlled by adjusting cell-matrix interactions. |
