| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biomacromolecular chaperone Refolding of denatured proteins mediated by the self-assembled nanoparticles |
| 초록 |
Protein refolding is the crucial process by which a misfolded protein assisted by molecular chaperones reconfigures to its characteristic functional active state. Here we have synthesized hydrophobically modified hyaluronic acid (HA) by chemically conjugating cholanic acid to HA backbone, in which the conjugate could form nanoparticles by self-assembly of cholanic acid. The physiochemical characteristics were investigated by 1H NMR, dynamic light scattering, flourescence spectrophotometer. The chaperon-like activity was evaluated using carbonic anhydrase B (CAB) as a model protein and β-cyclodextrins as a releasing agent. This artificial chaperone can be useful as protein stabilizing and sustained delivery system. |
| 저자 |
강아름, 박재형
|
| 소속 |
경희대 |
| 키워드 |
chaperone; hyaluronic acid; cholanic acid;
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| E-Mail |
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