| 초록 |
In this work, by mimicking the cell membranes in nature, we aim to create ion-selective artificial membranes that contain molecular recognition-based synthetic channels. The selective permeability system is based on an innovative modular approach; it is composed of a freestanding lipid bilayer, ion-binding nucleic acid nanostructure, and hydrophobic anchor for lipid incorporation. We rationally designed and chemically synthesized the artificial potassium channels by hydrophobic modification of G-quadruplex DNA structures, which are well-known to specifically bind potassium ions. We successfully confirmed the formation of potassium binding structures using circular dichroism spectroscopy and subsequently visualized their lipid insertion through confocal microscopy. Importantly, lipid bilayer recording through an electronic device validated the selective ion permeability of our synthetic membranes; among diverse alkali metal ions, our channels preferentially transported potassium ions. |
